Una nueva teoría patogénica de las enfermedades inflamatorias reumáticas. Niveles patogénica

Resumen: Proponemos un nuevo punto de vista en patogénica reumática se queja relacionada con el éxito que tuvimos y tenemos en los testículos preclínicos y clínicos con el tratamiento PL, antioxidantes y oxigenoterapia por vía intravenosa.

El trastorno de tejido principal en las enfermedades reumáticas (generalmente hablando) es producido por OFR (El oxígeno libre Radicales) agresión. Todos los otros desequilibrios bioquímicos e inmunológicos son consecuencias de la agresión OFR. Para que proponemos Niveles patogénica (una herramienta para ayudar a nuestra comprensión) que son útiles en la explicación de que la nueva teoría patogénica: El nivel genético; el nivel de los malos orgánica; nivel-histo bioquímica y el nivel cuántico.

El estudio de las enfermedades reumáticas espectáculos, en algunas enfermedades reumáticas específicas, un complejo de trastornos bioquímicos e inmunológicos. La artritis reumatoide – la “clásico” enfermedad inflamatoria crónica es una enfermedad autoinmune con exceso de antígeno y una posible HLA DR4 (histocompatibilidad). La Espondilitis Anquilosante es también una enfermedad reumática inflamatoria crónica pero con una participación inmunológica menos importante: un posible aumento de la IgG y las IgM Imunoglobulines en más de 60% de las personas enfermas pero con una determinación de histocompatibilidad fuerte (HLA B27). La osteoartrosis es una enfermedad degenerativa y de edad condiciones influido sin inmunológica o participación HLA.

A pesar de estas diferencias clínicas en la práctica sólo a finales de los estados de enfermedad nos encontramos con una clara delimitación. En las primeras etapas de la reumática se queja de que en algún momento es muy difícil decir si la persona enferma tiene un trastorno osteoarthosis con afectación inflamatoria o es el comienzo de una enfermedad reumatoide. Podemos encontrar muchas otras situaciones fronterizas entre las enfermedades reumáticas inflamatorias o degenerativas.

El tratamiento clásico hoy en día es diferente para la artritis (La artritis reumatoide) la osteoartrosis, o los diferentes tipos de mialgias. En lugar de este punto de vista que tratamos de mostrar que existe una gran unificación de la condición patogénica y la consecuencia es un mismo tratamiento posible. La condición es pathogenycal en los cambios bioquímicos en los tejidos, pero el desequilibrio bioquímico es debido a la “energético” desequilibrio en los cuantos. Mi padre, médico Alexandru Savulescu y el padre del tratamiento PL, radios acerca desequilibrio energético sin especificación. Si usamos sólo el término “energético’ es a grande y nos falta de delimitaciones. Como veremos más adelante, si utilizamos “energías quanta” es decir lo mismo pero con un subterráneo específico. Para que proponemos cuatro niveles diferentes patogénica (PathLe), que es una separación artificial útil para entender lo que tenemos que decir.

Yo. La primera PathLe es la genética, que es determinístico y probabilístico. Esto significa que no se puede escapar de su determinación (tienes que ser tan) y la posibilidad de desarrollar una enfermedad específica es probabilística cuando no es determinista.

II. El segundo PathLe es el enfermo orgánico. Es la enfermedad. Sólo a este nivel podemos tener un diagnóstico.

III. La tercera es la biochemie celular. Desequilibrio en la vida de la célula. Estos cambios pueden estar presentes antes de la aparición de los síntomas clínicos.

IV. El cuarto PathLe es la cuántica. Eso significa que los cambios bioquímicos en las células, el comienzo de la enfermedad e incluso la determinación probabilística de HLA puede depende de la excitación atómica cuántica (energía).

El nivel genético está representado por un sistema poligénico, a saber, el sistema HLA, cuyos genes tienen diferentes sitios en los cromosomas del par VI, ser clasificados en tres grupos distintos: 1.HLA A, HLA B< HLA C; 2.The HLA D and HLADR genes; 3.The complements and the proactivators of the C3 Fraction. The HLA D, DR and B genes inducing an intensive proliferation, particularly of the B lymphocites cells with a protective role. They are important in the chronic rheumatic inflammatory diseases. All these genes produce tissue antigen of glycoproteic nature. The whole system of tissue HLA antigens polygenically controlled is a fractional unity involved in the non-self recognition. The HLA system acts in close connection with plasma immunoglobulins, which, in their turn, are under a rigorous genetic control. The HLA DR4 system is present in over 40% Rheumatoid Arthritis (RA) patients. In the Ankylosing Spondylitis (AS), according to some authors, the HLA B27 is found in over 90% patients. The ill organic level comprises, in the Arthritis (RA), what we call the “disease”, the autoimmune aggression. Changes in connective tissue an in bones, pains, articular stiffness, synovial proliferation with tumefaction and in the late stages bone destruction and ankylosing. In autoimmune diseases (Rheumatoid Arthritis) we may met the following steps: The setting of the immune complexes through an antigen excess followed by complement addition, platelet injury leading to the releasing of vasoactive biologic amines (kallikrein, bradyquinin, bradyquininogen, etc.), the increase of the vascular permeability by the factors released by platelets and white cells, the localisation of the immune complexes on vascular walls, releasing of chemo tactic factors (opsonines), tissue infiltration by polynuclear cells and macrophages with immune complexes ingestion, lysosome realising leading to increase in tissue proteolysis (rheumatic factor, reactive c protein, plasma immunoglobuline, a.s.o.). The histo biochemical level is represented by biochemical changes in the tissues, at the cellular level. The cellular membrane may be damaged by the poly-unsaturated fatty acids (phospholipids) per oxidation leading to eicosanoid formation (arachidonic acid, prostaglandin’s, Thromboxanes, leucotriens and other lipoxins). The chemical species called Oxygen Free Radicals (OFR) which is ubicuitary because they are made up and released by cells (especially leucocyte cells) and which are close related with lipid per oxidation. The most important OFR are: the single turning rapidly into super oxide, a species with high toxicity and able to initiate some chain reactions; the hydrogen peroxide, less noxious but able to form oxidril radical more toxic. Tissues have natural protection by the Antioxidative System (AOS): superoxid-dismutase (SOD), catalase, peroxidase, cytocronoxidases and macrocortin (lipomodulin) an A2 pfospholipase inhibitor, substances which have the ability to protect against the toxic action of OFR in excess. In pathological conditions this protection is ineffective. The excess of OFR may lead to cell destruction, proteolysis, with auto antigens production. The quantic level is that of intra-atomic changes. There are more possible atomic and molecular orbital depending of number of electrons, spin movement and molecular energetical charge. When a molecule receives energy it become “exited” and the electrons begin to change their orbital. In the Plasma (the forth state of matter) all the electrons are leaving the atoms because of the great energy, the Maxine of oxidation. At the beginning of the OFR studies they find them in radiation conditions. This confer them an oxidative power which depend both on chemical species (super oxides, oxidril radicals) and of the quantic excitation. In the body the quantic excitation may depend on different factors like: toxic substances, ionising radiations (exposure to the sun light), microbian or viral invasion, traumas, some metallic ions, exogenous oxidative enzymes. a.s.o. Interrelations between the pathogenic levels. This frame of pathogenic levels is artificial but necessary for our intention of changing the medical thinking upon the usefulness if the nosological entities, (different diseases, different treatments) and to propose an other approach, more ethiopatogenical which may lead to a different understanding of the treatment. There are important interdependences between pathogenical levels difficult to separate. First important observation is that is an important difference between the molecular oxygen, which helps us to move the acid conditions in the tissues (respiration, tissue oxygenation) and the OFR species. The molecular oxygen is not “exited”, their electrons are in stable orbital and are no ready to level their substrate, the oxygen molecules. The OFR species are “exited”, they dun proteolysis, cellular destructions. In pathological inflammatory conditions (like in reumativcal diseases) They grow in number and they become more and more excited. Way? Genetical determination by HLA, possible microbian or viral aggression and immune complex apparition. The firs autoagression is that of the OFR species which, as we say, grow in number and became exited. The consequence is the proteolysis witch lead to the immune complex formation and a second auto aggression, the immune auto aggression is at the start. We repeat. In some special conditions we call pathological, and only in some conditions, the OFR, present all over the body in health conditions, grows in number and became more and more excited, more and more, fool of energies (we call quantic energies), more and more loosing electrons. In pathological conditions a lot of OFR may appear in soft tissues as muscles, connective tissue (sinovia, tendons, fasciae) and they burn this tissues. The immediate consequences are: pain, stiffness, redness, swelling (calor, rubor, dolor, tumor, as in all inflammatory conditions). Proteolysis is the chemical effect by which OFR may reduce their excitability and even may scavenge them. This is the “natural” kind of self treatment the body has. More consequences: Denaturised proteins stimulate the Immune complex formation and after several moth, or years, of pains, swelling and treatment with AINS, or other anti-inflammatory medicines, joints may be affected and even ankylosing may occur. That is the case in arthitis. In AS the Para vertebral destroyed connective tissues and muscles (the OFR aggression is focused on the spine- genetic aleatory determination). Became fibrous (fibrous Para vertebral ligaments with a fibrous ankylosing) and after another time the ankylosing will turn in osseous ankylosing. Because of the long period of big muscular and connective pains patients are obliged to reach vicious position in flexion and the ankylosing follow it. In Osteoarthrosis is the same situation but with less important OFR aggression. Proteolysis leads to the articular deformation, condensing osteitis. We come back to our mind. The first auto aggression is the OFR aggression. The mesenchime, muscle, connective tissue and only after a long period of pains and swelling the joint and generally the bones are involved. The firs injury is in the soft tissue. That means that the pathogenical differences between different rheumatic diseases, arthritis, AS, Osteoarthritis, is genetically aleatory determined and maybe extern influences. Immediate consequences: All the Anti-inflammatory treatments and immune treatments skips the quantic level auto aggression and may no change the ill evolution, no mach recovery in rheumatic diseases. Our PL treatment with a dilution of little chains of polypeptides may be a help in the local scavenge of OFR. The natural scavenge (AOS) with superoxid- dis- mutase, catalase, different kinds of peroxidases has no a real power in pathological conditions, even C Vitamin, E and A Vitamin, Selenium, by food or administrated as a supplement has no power to scavenge OFR. By local and regional injections with PL we offer a very good local scavenger of the OFR species. The Homoeopahtical dilutions of PL (PL2 or 3- Hahnemannian dilutions) by their clusters (water crystals) may help by their chemical phantoms which may scavenge OFR like the chemical species (Polypeptides). Second important observation. In the medical literature there is an ambiguity between the healthy Oxygen species witch help us to avoid cellular acidosis and the OFR species which are weapons as antimicrobian or antiviral aggression. The healthy oxygen species are in a low quantic excitation and for that has no a proteolysis effect. The OFR species have a great energetic charge and that means an excited quantic state with a power fool force of oxidation, of proteolysis. For that the intravenous treatment, we use to, with oxygen peroxide in low dilution may help against cellular acidosis and is no harm as an OFR.
Conclusión.

Todas las enfermedades reumáticas tienen las mismas condiciones patogénica. Las diferencias entre la Artritis, Como y Osteoarthosis es HLA aleatoria dependiente y por las condiciones exteriores.
La enfermedad es la OFR Autoagression. La agresión Auto inmunológica es secundario.
El tratamiento PL es un carroñero locales OFR.

Copyright © Geo Savulescu 2003