Una teoria nuova Pathogenical delle malattie reumatiche infiammatorie. Livelli Pathogenical

Riassunto: Proponiamo un nuovo punto di vista pathogenical in reumatica lamenta legate al successo che abbiamo avuto e abbiamo in testicoli preclinici e clinici con il trattamento PL, antiossidanti e ossigeno terapia endovenosa.

Il disturbo del tessuto principale nelle malattie reumatiche (generale) è prodotto da OFR (Oxygen Free Radicals) aggressione. Tutti gli altri squilibri biochimici e immunologici sono conseguenze dell'aggressione OFR. Per questo proponiamo Livelli Pathogenical (uno strumento per aiutare la nostra comprensione) che sono utili nella spiegazione di tale nuova teoria pathogenical: Il livello di genetica; il livello di mal organico; il livello isto-biochimico e livello quantistico.

Lo studio delle malattie reumatiche spettacoli, in alcune malattie reumatiche specifiche, un complesso di disturbi biochimici e immunologici. L'artrite reumatoide – il “classico” malattia infiammatoria cronica è una condizione autoimmune con eccesso di antigene e una possibile HLA DR4 (istocompatibilità). La spondilite anchilosante è una malattia reumatica infiammatoria cronica, ma con un meno importante partecipazione immunologica: un possibile aumento delle IgG e le IgM Imunoglobulines in oltre 60% delle persone malate, ma con una forte determinazione di istocompatibilità (HLA B27). L'osteoartrosi è una degenerative e di età condizioni influenzato senza immunologica o coinvolgimento HLA.

Nonostante questo le differenze cliniche nella pratica solo nel tardo stati di malattia troviamo una chiara delimitazione. Nelle prime fasi del reumatica lamenta è a volte molto difficile dire se il malato ha un disturbo osteoarthosis con interessamento infiammatorio o è un inizio di una malattia reumatoide. Possiamo trovare molte altre situazioni di confine tra malattie reumatiche infiammatorie o degenerative.

Il trattamento classico oggi è diverso per l'artrite (Artrite reumatoide) l'osteoartrosi, oppure i diversi tipi di mialgias. Invece di questo punto di vista cerchiamo di dimostrare che esiste una grande unificazione della condizione patogena e la conseguenza è un medesimo trattamento possibile. La condizione pathogenycal è nei cambiamenti bio-chimici nei tessuti, ma lo squilibrio biochimico è dovuto al “energetico” squilibrio in quanti. Mio padre, medico Alexandru Savulescu e il padre del trattamento PL, raggi merito squilibrio energetico senza specifica. Se usiamo solo il termine “energetico’ è di grande e ci manca di delimitazioni. Come vedremo in seguito, se usiamo “Quanta energia” vale a dire lo stesso ma con una sotterranea specifico. Per questo proponiamo quattro diversi livelli pathogenical (PathLe), che è una separazione artificiale utile per capire che cosa dobbiamo dire.

Io. Il primo PathLe è la genetica, che è deterministica e probabilistica. Ciò significa che non si può sfuggire la sua determinazione (è necessario essere così) e la possibilità di sviluppare una malattia specifica è probabilistica quando non è deterministica.

II. Il secondo PathLe è il malato organico. E 'la malattia. Solo a questo livello possiamo avere una diagnosi.

III. Il terzo è il biochemie cellulare. Sbilanciare nella vita delle cellule. Tali cambiamenti possono essere presenti prima della comparsa dei sintomi clinici.

IV. Il quarto PathLe è il quantum. Ciò significa che le variazioni biochimiche nelle cellule, l'inizio della malattia e anche la determinazione probabilistica HLA può variare a seconda della eccitazione atomico quantistico (energia).

Il livello genetico è rappresentato da un sistema poligenico, ossia il sistema HLA, i cui geni hanno siti diversi sui cromosomi della coppia VI, essere classificati in tre gruppi distinti: 1.HLA A, HLA B< HLA C; 2.The HLA D and HLADR genes; 3.The complements and the proactivators of the C3 Fraction. The HLA D, DR and B genes inducing an intensive proliferation, particularly of the B lymphocites cells with a protective role. They are important in the chronic rheumatic inflammatory diseases. All these genes produce tissue antigen of glycoproteic nature. The whole system of tissue HLA antigens polygenically controlled is a fractional unity involved in the non-self recognition. The HLA system acts in close connection with plasma immunoglobulins, which, in their turn, are under a rigorous genetic control. The HLA DR4 system is present in over 40% Rheumatoid Arthritis (RA) patients. In the Ankylosing Spondylitis (AS), according to some authors, the HLA B27 is found in over 90% patients. The ill organic level comprises, in the Arthritis (RA), what we call the “disease”, the autoimmune aggression. Changes in connective tissue an in bones, pains, articular stiffness, synovial proliferation with tumefaction and in the late stages bone destruction and ankylosing. In autoimmune diseases (Rheumatoid Arthritis) we may met the following steps: The setting of the immune complexes through an antigen excess followed by complement addition, platelet injury leading to the releasing of vasoactive biologic amines (kallikrein, bradyquinin, bradyquininogen, etc.), the increase of the vascular permeability by the factors released by platelets and white cells, the localisation of the immune complexes on vascular walls, releasing of chemo tactic factors (opsonines), tissue infiltration by polynuclear cells and macrophages with immune complexes ingestion, lysosome realising leading to increase in tissue proteolysis (rheumatic factor, reactive c protein, plasma immunoglobuline, a.s.o.). The histo biochemical level is represented by biochemical changes in the tissues, at the cellular level. The cellular membrane may be damaged by the poly-unsaturated fatty acids (phospholipids) per oxidation leading to eicosanoid formation (arachidonic acid, prostaglandin’s, Thromboxanes, leucotriens and other lipoxins). The chemical species called Oxygen Free Radicals (OFR) which is ubicuitary because they are made up and released by cells (especially leucocyte cells) and which are close related with lipid per oxidation. The most important OFR are: the single turning rapidly into super oxide, a species with high toxicity and able to initiate some chain reactions; the hydrogen peroxide, less noxious but able to form oxidril radical more toxic. Tissues have natural protection by the Antioxidative System (AOS): superoxid-dismutase (SOD), catalase, peroxidase, cytocronoxidases and macrocortin (lipomodulin) an A2 pfospholipase inhibitor, substances which have the ability to protect against the toxic action of OFR in excess. In pathological conditions this protection is ineffective. The excess of OFR may lead to cell destruction, proteolysis, with auto antigens production. The quantic level is that of intra-atomic changes. There are more possible atomic and molecular orbital depending of number of electrons, spin movement and molecular energetical charge. When a molecule receives energy it become “exited” and the electrons begin to change their orbital. In the Plasma (the forth state of matter) all the electrons are leaving the atoms because of the great energy, the Maxine of oxidation. At the beginning of the OFR studies they find them in radiation conditions. This confer them an oxidative power which depend both on chemical species (super oxides, oxidril radicals) and of the quantic excitation. In the body the quantic excitation may depend on different factors like: toxic substances, ionising radiations (exposure to the sun light), microbian or viral invasion, traumas, some metallic ions, exogenous oxidative enzymes. a.s.o. Interrelations between the pathogenic levels. This frame of pathogenic levels is artificial but necessary for our intention of changing the medical thinking upon the usefulness if the nosological entities, (different diseases, different treatments) and to propose an other approach, more ethiopatogenical which may lead to a different understanding of the treatment. There are important interdependences between pathogenical levels difficult to separate. First important observation is that is an important difference between the molecular oxygen, which helps us to move the acid conditions in the tissues (respiration, tissue oxygenation) and the OFR species. The molecular oxygen is not “exited”, their electrons are in stable orbital and are no ready to level their substrate, the oxygen molecules. The OFR species are “exited”, they dun proteolysis, cellular destructions. In pathological inflammatory conditions (like in reumativcal diseases) They grow in number and they become more and more excited. Way? Genetical determination by HLA, possible microbian or viral aggression and immune complex apparition. The firs autoagression is that of the OFR species which, as we say, grow in number and became exited. The consequence is the proteolysis witch lead to the immune complex formation and a second auto aggression, the immune auto aggression is at the start. We repeat. In some special conditions we call pathological, and only in some conditions, the OFR, present all over the body in health conditions, grows in number and became more and more excited, more and more, fool of energies (we call quantic energies), more and more loosing electrons. In pathological conditions a lot of OFR may appear in soft tissues as muscles, connective tissue (sinovia, tendons, fasciae) and they burn this tissues. The immediate consequences are: pain, stiffness, redness, swelling (calor, rubor, dolor, tumor, as in all inflammatory conditions). Proteolysis is the chemical effect by which OFR may reduce their excitability and even may scavenge them. This is the “natural” kind of self treatment the body has. More consequences: Denaturised proteins stimulate the Immune complex formation and after several moth, or years, of pains, swelling and treatment with AINS, or other anti-inflammatory medicines, joints may be affected and even ankylosing may occur. That is the case in arthitis. In AS the Para vertebral destroyed connective tissues and muscles (the OFR aggression is focused on the spine- genetic aleatory determination). Became fibrous (fibrous Para vertebral ligaments with a fibrous ankylosing) and after another time the ankylosing will turn in osseous ankylosing. Because of the long period of big muscular and connective pains patients are obliged to reach vicious position in flexion and the ankylosing follow it. In Osteoarthrosis is the same situation but with less important OFR aggression. Proteolysis leads to the articular deformation, condensing osteitis. We come back to our mind. The first auto aggression is the OFR aggression. The mesenchime, muscle, connective tissue and only after a long period of pains and swelling the joint and generally the bones are involved. The firs injury is in the soft tissue. That means that the pathogenical differences between different rheumatic diseases, arthritis, AS, Osteoarthritis, is genetically aleatory determined and maybe extern influences. Immediate consequences: All the Anti-inflammatory treatments and immune treatments skips the quantic level auto aggression and may no change the ill evolution, no mach recovery in rheumatic diseases. Our PL treatment with a dilution of little chains of polypeptides may be a help in the local scavenge of OFR. The natural scavenge (AOS) with superoxid- dis- mutase, catalase, different kinds of peroxidases has no a real power in pathological conditions, even C Vitamin, E and A Vitamin, Selenium, by food or administrated as a supplement has no power to scavenge OFR. By local and regional injections with PL we offer a very good local scavenger of the OFR species. The Homoeopahtical dilutions of PL (PL2 or 3- Hahnemannian dilutions) by their clusters (water crystals) may help by their chemical phantoms which may scavenge OFR like the chemical species (Polypeptides). Second important observation. In the medical literature there is an ambiguity between the healthy Oxygen species witch help us to avoid cellular acidosis and the OFR species which are weapons as antimicrobian or antiviral aggression. The healthy oxygen species are in a low quantic excitation and for that has no a proteolysis effect. The OFR species have a great energetic charge and that means an excited quantic state with a power fool force of oxidation, of proteolysis. For that the intravenous treatment, we use to, with oxygen peroxide in low dilution may help against cellular acidosis and is no harm as an OFR.
Conclusione.

Tutte le malattie reumatiche hanno le stesse condizioni pathogenical. Le differenze tra dolori articolari, Come e Osteoarthosis è HLA aleatoria dipendente e per le condizioni esterne.
La malattia è l'OFR Autoagression. L'aggressione Auto immunologico è secondario.
Il trattamento PL è un tesoro OFR locale.

Copyright © Geo Savulescu 2003