En ny Pathogenical Theory of revmatiske betennelsessykdommer. Pathogenical Levels

Oppsummering: Vi foreslår en ny pathogenical synspunkt i revmatisk klager relatert til den suksessen vi har hatt, og vi har i prekliniske og kliniske testiklene med PL behandling, antioksidanter og intravenøs oksygenbehandling.

Hoved vev lidelse i revmatiske sykdommer (generelt sett) er produsert av ofr (Oxygen Free Radicals) aggresjon. Alle de andre biokjemiske og immunologiske ubalanser er konsekvensene av OFR aggresjon. For at foreslår vi Pathogenical Levels (et verktøy for å hjelpe forståelsen) som er anvendelige ved beskrivelse av den nye pathogenical teori: Den genetiske nivå; ill-organisk nivå; den histo-biokjemisk nivå og kvante-nivå.

Studiet av de revmatiske sykdommer show, i enkelte revmatiske sykdommer, en kompleks biokjemiske og immunologiske lidelser. Den Revmatoid Artritt – den “klassisk” kronisk inflammatorisk sykdom er en autoimmun tilstand med antigen og en mulig HLA DR4 (histocompatibility). Den Bekhterevs sykdom er også en kronisk inflammatorisk revmatisk sykdom, men med en mindre viktig immunologisk deltakelse: en mulig økning av IgG-og IgM-Imunoglobulines i løpet 60% av de syke personer, men med en sterkt histocompatibility bestemmelse (HLA B27). Den osteoartrose er en degenerative og alder påvirket forhold uten immunologisk eller HLA engasjement.

På tross av denne kliniske forskjeller i praksis bare i de sene sykdomstilstander finner vi en klar avgrensning. I de tidlige stadiene av revmatiske klager det er en gang veldig vanskelig å si om den syke personen har et osteoarthosis lidelse med inflammatorisk engasjement eller er en begynnelse av en revmatisk sykdom. Vi kan finne mange andre grensesituasjoner mellom inflammatoriske eller degenerative revmatiske lidelser.

Den klassiske behandlingen er i dag forskjellig for leddgikt (Revmatoid artritt) den osteoartrose, eller de forskjellige typer mialgias. I stedet for dette synspunkt vi prøve å vise at det finnes en stor samling av den sykdomsfremkallende tilstand, og konsekvensen er en samme mulig behandling. Den pathogenycal tilstand er de bio-kjemiske forandringer i vevene, men biokjemisk ubalanse skyldes “energisk” ubalanse i kvanter. Min far, lege Alexandru Savulescu og far til PL behandling, eiker om energisk ubalanse uten spesifikasjon. Hvis vi bruker bare begrepet “energisk’ er til stor og vi mangler av avgrensninger. Som vi skal se nedenfor, hvis vi bruker “Quanta energier” er å si det samme, men med en bestemt jordisk. For at vi foreslår fire forskjellige pathogenical nivåer (PathLe), som er en kunstig separasjon nyttig for å forstå hva vi trenger å si.

Jeg. Den første PathLe er Genetic, som er deterministisk og sannsynlighets. Det betyr at du ikke kan unnslippe sin besluttsomhet (du trenger å være så) og muligheten til å utvikle en bestemt sykdom er sannsynlighets når det ikke er deterministisk.

II. Den andre PathLe er syk organisk. Det er sykdommen. Bare på dette nivået kan vi ha en diagnose.

III. Den tredje er cellen Biochemie. Ubalanse i cellen livet. Slike endringer kan være til stede før forekomsten av de kliniske symptomene.

IV. Den fjerde PathLe er kvante. Det betyr at biokjemiske endringer i cellene, begynnelsen av sykdommen, og til og med HLA sannsynlighetsbestemmelse kan avhenger av kvante atom eksitasjon (energi).

Genetisk nivå er representert ved en polygenic system, nemlig HLA systemet, hvis gener har ulike steder på kromosomene i vith pair, blir klassifisert i tre grupper: 1.HLA A, HLA B< HLA C; 2.The HLA D and HLADR genes; 3.The complements and the proactivators of the C3 Fraction. The HLA D, DR and B genes inducing an intensive proliferation, particularly of the B lymphocites cells with a protective role. They are important in the chronic rheumatic inflammatory diseases. All these genes produce tissue antigen of glycoproteic nature. The whole system of tissue HLA antigens polygenically controlled is a fractional unity involved in the non-self recognition. The HLA system acts in close connection with plasma immunoglobulins, which, in their turn, are under a rigorous genetic control. The HLA DR4 system is present in over 40% Rheumatoid Arthritis (RA) patients. In the Ankylosing Spondylitis (AS), according to some authors, the HLA B27 is found in over 90% patients. The ill organic level comprises, in the Arthritis (RA), what we call the “disease”, the autoimmune aggression. Changes in connective tissue an in bones, pains, articular stiffness, synovial proliferation with tumefaction and in the late stages bone destruction and ankylosing. In autoimmune diseases (Rheumatoid Arthritis) we may met the following steps: The setting of the immune complexes through an antigen excess followed by complement addition, platelet injury leading to the releasing of vasoactive biologic amines (kallikrein, bradyquinin, bradyquininogen, etc.), the increase of the vascular permeability by the factors released by platelets and white cells, the localisation of the immune complexes on vascular walls, releasing of chemo tactic factors (opsonines), tissue infiltration by polynuclear cells and macrophages with immune complexes ingestion, lysosome realising leading to increase in tissue proteolysis (rheumatic factor, reactive c protein, plasma immunoglobuline, a.s.o.). The histo biochemical level is represented by biochemical changes in the tissues, at the cellular level. The cellular membrane may be damaged by the poly-unsaturated fatty acids (phospholipids) per oxidation leading to eicosanoid formation (arachidonic acid, prostaglandin’s, Thromboxanes, leucotriens and other lipoxins). The chemical species called Oxygen Free Radicals (OFR) which is ubicuitary because they are made up and released by cells (especially leucocyte cells) and which are close related with lipid per oxidation. The most important OFR are: the single turning rapidly into super oxide, a species with high toxicity and able to initiate some chain reactions; the hydrogen peroxide, less noxious but able to form oxidril radical more toxic. Tissues have natural protection by the Antioxidative System (AOS): superoxid-dismutase (SOD), catalase, peroxidase, cytocronoxidases and macrocortin (lipomodulin) an A2 pfospholipase inhibitor, substances which have the ability to protect against the toxic action of OFR in excess. In pathological conditions this protection is ineffective. The excess of OFR may lead to cell destruction, proteolysis, with auto antigens production. The quantic level is that of intra-atomic changes. There are more possible atomic and molecular orbital depending of number of electrons, spin movement and molecular energetical charge. When a molecule receives energy it become “exited” and the electrons begin to change their orbital. In the Plasma (the forth state of matter) all the electrons are leaving the atoms because of the great energy, the Maxine of oxidation. At the beginning of the OFR studies they find them in radiation conditions. This confer them an oxidative power which depend both on chemical species (super oxides, oxidril radicals) and of the quantic excitation. In the body the quantic excitation may depend on different factors like: toxic substances, ionising radiations (exposure to the sun light), microbian or viral invasion, traumas, some metallic ions, exogenous oxidative enzymes. a.s.o. Interrelations between the pathogenic levels. This frame of pathogenic levels is artificial but necessary for our intention of changing the medical thinking upon the usefulness if the nosological entities, (different diseases, different treatments) and to propose an other approach, more ethiopatogenical which may lead to a different understanding of the treatment. There are important interdependences between pathogenical levels difficult to separate. First important observation is that is an important difference between the molecular oxygen, which helps us to move the acid conditions in the tissues (respiration, tissue oxygenation) and the OFR species. The molecular oxygen is not “exited”, their electrons are in stable orbital and are no ready to level their substrate, the oxygen molecules. The OFR species are “exited”, they dun proteolysis, cellular destructions. In pathological inflammatory conditions (like in reumativcal diseases) They grow in number and they become more and more excited. Way? Genetical determination by HLA, possible microbian or viral aggression and immune complex apparition. The firs autoagression is that of the OFR species which, as we say, grow in number and became exited. The consequence is the proteolysis witch lead to the immune complex formation and a second auto aggression, the immune auto aggression is at the start. We repeat. In some special conditions we call pathological, and only in some conditions, the OFR, present all over the body in health conditions, grows in number and became more and more excited, more and more, fool of energies (we call quantic energies), more and more loosing electrons. In pathological conditions a lot of OFR may appear in soft tissues as muscles, connective tissue (sinovia, tendons, fasciae) and they burn this tissues. The immediate consequences are: pain, stiffness, redness, swelling (calor, rubor, dolor, tumor, as in all inflammatory conditions). Proteolysis is the chemical effect by which OFR may reduce their excitability and even may scavenge them. This is the “natural” kind of self treatment the body has. More consequences: Denaturised proteins stimulate the Immune complex formation and after several moth, or years, of pains, swelling and treatment with AINS, or other anti-inflammatory medicines, joints may be affected and even ankylosing may occur. That is the case in arthitis. In AS the Para vertebral destroyed connective tissues and muscles (the OFR aggression is focused on the spine- genetic aleatory determination). Became fibrous (fibrous Para vertebral ligaments with a fibrous ankylosing) and after another time the ankylosing will turn in osseous ankylosing. Because of the long period of big muscular and connective pains patients are obliged to reach vicious position in flexion and the ankylosing follow it. In Osteoarthrosis is the same situation but with less important OFR aggression. Proteolysis leads to the articular deformation, condensing osteitis. We come back to our mind. The first auto aggression is the OFR aggression. The mesenchime, muscle, connective tissue and only after a long period of pains and swelling the joint and generally the bones are involved. The firs injury is in the soft tissue. That means that the pathogenical differences between different rheumatic diseases, arthritis, AS, Osteoarthritis, is genetically aleatory determined and maybe extern influences. Immediate consequences: All the Anti-inflammatory treatments and immune treatments skips the quantic level auto aggression and may no change the ill evolution, no mach recovery in rheumatic diseases. Our PL treatment with a dilution of little chains of polypeptides may be a help in the local scavenge of OFR. The natural scavenge (AOS) with superoxid- dis- mutase, catalase, different kinds of peroxidases has no a real power in pathological conditions, even C Vitamin, E and A Vitamin, Selenium, by food or administrated as a supplement has no power to scavenge OFR. By local and regional injections with PL we offer a very good local scavenger of the OFR species. The Homoeopahtical dilutions of PL (PL2 or 3- Hahnemannian dilutions) by their clusters (water crystals) may help by their chemical phantoms which may scavenge OFR like the chemical species (Polypeptides). Second important observation. In the medical literature there is an ambiguity between the healthy Oxygen species witch help us to avoid cellular acidosis and the OFR species which are weapons as antimicrobian or antiviral aggression. The healthy oxygen species are in a low quantic excitation and for that has no a proteolysis effect. The OFR species have a great energetic charge and that means an excited quantic state with a power fool force of oxidation, of proteolysis. For that the intravenous treatment, we use to, with oxygen peroxide in low dilution may help against cellular acidosis and is no harm as an OFR.
Konklusjon.

Alle revmatiske sykdommer har de samme betingelser pathogenical. Forskjellene mellom arthitis, Som og Osteoarthosis er aleatory HLA avhengig og for de ytre forholdene.
Sykdommen er den OFR Autoagression. Den immunologiske Auto aggresjon er sekundær.
Den PL behandling er en lokal ofr åtseldyr.

Copyright © Geo Savulescu 2003