风湿性炎性疾病的新Pathogenical理论. Pathogenical水平

总结: 我们建议在风湿性新pathogenical的角度抱怨与我们有成功,我们在临床前和临床睾丸与PL治疗, 抗氧化剂和静脉氧疗.

主要的组织障碍风湿性疾病 (一般来说) 是由氧自由基产生 (氧自由基) 侵略. 所有其它的生化和免疫失衡是氧自由基攻击的后果. 为此,我们提出Pathogenical水平 (一个工具来帮助我们的理解) 这在新的pathogenical理论的解释是有用: 在遗传学水平; 不周有机级; A组织生化水平和量子水平.

的风湿性疾病显示研究, 在一些具体的风湿性疾病, 一个复杂的生化及免疫疾病. 类风湿关节炎 – 该 “经典” 慢性炎性疾病是自身免疫疾病与抗原过量和可能的HLA DR4 (组织相容性). 在强直性脊柱炎也是一种慢性炎性风湿性疾病,而是一个不太重要的免疫参与: 的IgG和IgM抗体Imunoglobulines在超过可能增加 60% 的病患者,但具有较强的组织相容性测定 (人类白细胞抗原B27). 在骨关节病是没有免疫或HLA参与退化和年龄的影响情况.

尽管在实践中这种临床差异只在疾病的晚期状态,我们找到一个明确的划界. 在风湿病的早期阶段会抱怨有时是真的很难说,如果生病的人有一个osteoarthosis症的炎症介入,或者是类风湿疾病的开始. 我们可能会发现炎症或退行性风湿性疾病之间有许多其他边境局势.

经典的治疗现在是不同的关节炎 (类风湿关节炎) 在骨关节病, 或不同种类的mialgias. 代替这个角度来看,我们尝试表明,存在的致病条件的大统一和后果是相同的可能的治疗. 该pathogenycal条件是在组织中的生化改变, 但生化失衡是由于 “有活力” 不平衡量子. 我的父亲, 医生亚历山萨乌莱斯和PL治疗之父, 关于辐条不规范的充满活力的不平衡. 如果我们只使用术语 “有活力’ 是到大,我们缺乏划界的. 正如我们下面将看到的, 如果我们使用 “量子能量” 就是说相同,但与特定的地下. 为此,我们提出了四种不同的pathogenical水平 (PathLe), 这是一种人为的分离理解我们需要说有用.

我. 第一PathLe是遗传, 这是确定性和概率. 这意味着你不能逃脱他的决心 (你需要这样) 并制定了具体的疾病的可能性是概率性的,当它不确定性.

二. 第二PathLe是生病有机. 这是病. 只有在这个层面上,我们可能有一个诊断.

三. 第三个是细胞BIOCHEMIE. 不平衡在细胞的生命. 这种变化可能是临床症状发生前存在.

四. 第四PathLe是量子. 这意味着,在细胞中的生物化学变化, 该疾病的开始,甚至与HLA概率性确定可依赖于量子原子激发 (能源).

基因水平是由多基因系统为代表, 即人类白细胞抗原系统, 它的基因有不同的网站上VITH对的染色体, 被分入三个不同的组: 1.HLA一, HLA乙< HLA C; 2.The HLA D and HLADR genes; 3.The complements and the proactivators of the C3 Fraction. The HLA D, DR and B genes inducing an intensive proliferation, particularly of the B lymphocites cells with a protective role. They are important in the chronic rheumatic inflammatory diseases. All these genes produce tissue antigen of glycoproteic nature. The whole system of tissue HLA antigens polygenically controlled is a fractional unity involved in the non-self recognition. The HLA system acts in close connection with plasma immunoglobulins, which, in their turn, are under a rigorous genetic control. The HLA DR4 system is present in over 40% Rheumatoid Arthritis (RA) patients. In the Ankylosing Spondylitis (AS), according to some authors, the HLA B27 is found in over 90% patients. The ill organic level comprises, in the Arthritis (RA), what we call the “disease”, the autoimmune aggression. Changes in connective tissue an in bones, pains, articular stiffness, synovial proliferation with tumefaction and in the late stages bone destruction and ankylosing. In autoimmune diseases (Rheumatoid Arthritis) we may met the following steps: The setting of the immune complexes through an antigen excess followed by complement addition, platelet injury leading to the releasing of vasoactive biologic amines (kallikrein, bradyquinin, bradyquininogen, etc.), the increase of the vascular permeability by the factors released by platelets and white cells, the localisation of the immune complexes on vascular walls, releasing of chemo tactic factors (opsonines), tissue infiltration by polynuclear cells and macrophages with immune complexes ingestion, lysosome realising leading to increase in tissue proteolysis (rheumatic factor, reactive c protein, plasma immunoglobuline, a.s.o.). The histo biochemical level is represented by biochemical changes in the tissues, at the cellular level. The cellular membrane may be damaged by the poly-unsaturated fatty acids (phospholipids) per oxidation leading to eicosanoid formation (arachidonic acid, prostaglandin’s, Thromboxanes, leucotriens and other lipoxins). The chemical species called Oxygen Free Radicals (OFR) which is ubicuitary because they are made up and released by cells (especially leucocyte cells) and which are close related with lipid per oxidation. The most important OFR are: the single turning rapidly into super oxide, a species with high toxicity and able to initiate some chain reactions; the hydrogen peroxide, less noxious but able to form oxidril radical more toxic. Tissues have natural protection by the Antioxidative System (AOS): superoxid-dismutase (SOD), catalase, peroxidase, cytocronoxidases and macrocortin (lipomodulin) an A2 pfospholipase inhibitor, substances which have the ability to protect against the toxic action of OFR in excess. In pathological conditions this protection is ineffective. The excess of OFR may lead to cell destruction, proteolysis, with auto antigens production. The quantic level is that of intra-atomic changes. There are more possible atomic and molecular orbital depending of number of electrons, spin movement and molecular energetical charge. When a molecule receives energy it become “exited” and the electrons begin to change their orbital. In the Plasma (the forth state of matter) all the electrons are leaving the atoms because of the great energy, the Maxine of oxidation. At the beginning of the OFR studies they find them in radiation conditions. This confer them an oxidative power which depend both on chemical species (super oxides, oxidril radicals) and of the quantic excitation. In the body the quantic excitation may depend on different factors like: toxic substances, ionising radiations (exposure to the sun light), microbian or viral invasion, traumas, some metallic ions, exogenous oxidative enzymes. a.s.o. Interrelations between the pathogenic levels. This frame of pathogenic levels is artificial but necessary for our intention of changing the medical thinking upon the usefulness if the nosological entities, (different diseases, different treatments) and to propose an other approach, more ethiopatogenical which may lead to a different understanding of the treatment. There are important interdependences between pathogenical levels difficult to separate. First important observation is that is an important difference between the molecular oxygen, which helps us to move the acid conditions in the tissues (respiration, tissue oxygenation) and the OFR species. The molecular oxygen is not “exited”, their electrons are in stable orbital and are no ready to level their substrate, the oxygen molecules. The OFR species are “exited”, they dun proteolysis, cellular destructions. In pathological inflammatory conditions (like in reumativcal diseases) They grow in number and they become more and more excited. Way? Genetical determination by HLA, possible microbian or viral aggression and immune complex apparition. The firs autoagression is that of the OFR species which, as we say, grow in number and became exited. The consequence is the proteolysis witch lead to the immune complex formation and a second auto aggression, the immune auto aggression is at the start. We repeat. In some special conditions we call pathological, and only in some conditions, the OFR, present all over the body in health conditions, grows in number and became more and more excited, more and more, fool of energies (we call quantic energies), more and more loosing electrons. In pathological conditions a lot of OFR may appear in soft tissues as muscles, connective tissue (sinovia, tendons, fasciae) and they burn this tissues. The immediate consequences are: pain, stiffness, redness, swelling (calor, rubor, dolor, tumor, as in all inflammatory conditions). Proteolysis is the chemical effect by which OFR may reduce their excitability and even may scavenge them. This is the “natural” kind of self treatment the body has. More consequences: Denaturised proteins stimulate the Immune complex formation and after several moth, or years, of pains, swelling and treatment with AINS, or other anti-inflammatory medicines, joints may be affected and even ankylosing may occur. That is the case in arthitis. In AS the Para vertebral destroyed connective tissues and muscles (the OFR aggression is focused on the spine- genetic aleatory determination). Became fibrous (fibrous Para vertebral ligaments with a fibrous ankylosing) and after another time the ankylosing will turn in osseous ankylosing. Because of the long period of big muscular and connective pains patients are obliged to reach vicious position in flexion and the ankylosing follow it. In Osteoarthrosis is the same situation but with less important OFR aggression. Proteolysis leads to the articular deformation, condensing osteitis. We come back to our mind. The first auto aggression is the OFR aggression. The mesenchime, muscle, connective tissue and only after a long period of pains and swelling the joint and generally the bones are involved. The firs injury is in the soft tissue. That means that the pathogenical differences between different rheumatic diseases, arthritis, AS, Osteoarthritis, is genetically aleatory determined and maybe extern influences. Immediate consequences: All the Anti-inflammatory treatments and immune treatments skips the quantic level auto aggression and may no change the ill evolution, no mach recovery in rheumatic diseases. Our PL treatment with a dilution of little chains of polypeptides may be a help in the local scavenge of OFR. The natural scavenge (AOS) with superoxid- dis- mutase, catalase, different kinds of peroxidases has no a real power in pathological conditions, even C Vitamin, E and A Vitamin, Selenium, by food or administrated as a supplement has no power to scavenge OFR. By local and regional injections with PL we offer a very good local scavenger of the OFR species. The Homoeopahtical dilutions of PL (PL2 or 3- Hahnemannian dilutions) by their clusters (water crystals) may help by their chemical phantoms which may scavenge OFR like the chemical species (Polypeptides). Second important observation. In the medical literature there is an ambiguity between the healthy Oxygen species witch help us to avoid cellular acidosis and the OFR species which are weapons as antimicrobian or antiviral aggression. The healthy oxygen species are in a low quantic excitation and for that has no a proteolysis effect. The OFR species have a great energetic charge and that means an excited quantic state with a power fool force of oxidation, of proteolysis. For that the intravenous treatment, we use to, with oxygen peroxide in low dilution may help against cellular acidosis and is no harm as an OFR.
结论.

所有的风湿性疾病有相同的pathogenical条件. Arthitis之间的差异, 由于和Osteoarthosis是偶然的HLA依赖和外部条件.
这种疾病是OFR Autoagression. 免疫自动攻击是次要的.
在PL治疗是一个本地氧自由基清除剂.

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