Povzetek: Mi predlagamo nov pathogenical stališče pri revmatičnih pritožuje, povezane z uspehom smo imeli in imamo v predkliničnih in kliničnih testisov z zdravljenjem PL, antioksidanti in intravensko zdravljenje s kisikom.
Glavni motnja tkiva pri revmatskih obolenjih (splošno) se proizvaja z OFR (Kisikove proste radikale) agresija. Vse druge biokemijske in imunološke neravnovesja posledice OFR agresije. Za to predlagamo Pathogenical Levels (orodje za razumevanje) ki so koristne pri razlagi tega novega pathogenical teoriji: Genetski ravni; ill-organski ravni; Raven histo-biokemični in nivo kvantne.
Študija o revmatičnih boleznih oddaj, v določenih revmatičnih bolezni, Kompleksna biokemične in imunološke motnje. Revmatoidni artritis – the “klasična” kronična vnetna bolezen avtoimunska stanja in z antigenom presegajo in morebitno HLA DR4 (histokompatibilnostnim). Ankilozirajoči spondilitis je kronična vnetna tudi revmatična bolezen, vendar z manj pomembno imunološko sodelovanja: možno povečanje IgG in IgM Imunoglobulines v več 60% od obolelih, vendar z odločno histokompatibilnostnim (HLA B27). Osteoartroze je degenerativna in starost vplivajo razmere brez imunološkega ali udeležbe HLA.
Kljub temu kliničnih razlik v praksi šele v poznih bolezenska stanja smo ugotovili, jasno razmejitev. V zgodnjih fazah revmatičnih pritožuje, da je včasih res težko reči, če je bolna oseba zbolel osteoarthosis z vnetno vpletenosti ali je začetek revmatoidnega bolezni. Mi lahko najdete številne druge mejne situacije med vnetnih ali degenerativnih revmatičnih obolenjih.
Klasično zdravljenje je danes drugačna za artritis (Revmatoidni artritis) osteoartroze, ali različne vrste mialgias. Namesto tega vidika bomo poskušali pokazati, da obstaja veliko poenotenje patogene stanju in posledica je enako mogoče zdravljenje. Pathogenycal stanje v bio-kemičnih sprememb v tkivih, vendar bio-kemično neravnovesje je posledica “energična” Neravnovesje v kvantov. Moj oče, Zdravnik Alexandru Savulescu in oče zdravljenje PL, napere o energična neravnovesje, brez specifikacij. Če bomo uporabili le izraz “energična’ je velika in mi pomanjkanje razmejitev. Kot bomo videli v nadaljevanju, če bomo uporabili “QUANTA energije” pomeni isto vendar z določeno pod zemljo. Za to predlagamo štiri različne pathogenical ravni (PathLe), ki je umetna ločitev uporaben pri razumevanju kar moramo reči.
I. Prvi PathLe je Genetska, ki je deterministična in verjetnostna. To pomeni, da ne more uiti svojo odločenost (morate biti tako) in možnost za oblikovanje posebne bolezni je verjetnostno ko ni determinističen.
II. Drugi PathLe je bolan organsko. To je bolezen. Samo na tej stopnji lahko imamo diagnozo.
III. Tretja je celica Biochemie. Neuravnoteženost v življenju celic. Takšne spremembe so lahko prisotni pred pojavom kliničnih simptomov.
IV. Četrti PathLe je kvantna. To pomeni, da biokemične spremembe v celicah, začetek bolezni in celo HLA verjetnostno določitev lahko odvisna od kvantne atomske vzbujanja (energije).
Genski ravni je predstavljen z poligenem sistem, sicer sistem HLA, katerega geni imajo različna mesta na kromosomih v šesti par, razvrstijo v tri različne skupine: 1.HLA, HLA B< HLA C; 2.The HLA D and HLADR genes; 3.The complements and the proactivators of the C3 Fraction.
The HLA D, DR and B genes inducing an intensive proliferation, particularly of the B lymphocites cells with a protective role. They are important in the chronic rheumatic inflammatory diseases. All these genes produce tissue antigen of glycoproteic nature.
The whole system of tissue HLA antigens polygenically controlled is a fractional unity involved in the non-self recognition. The HLA system acts in close connection with plasma immunoglobulins, which, in their turn, are under a rigorous genetic control.
The HLA DR4 system is present in over 40% Rheumatoid Arthritis (RA) patients. In the Ankylosing Spondylitis (AS), according to some authors, the HLA B27 is found in over 90% patients.
The ill organic level comprises, in the Arthritis (RA), what we call the “disease”, the autoimmune aggression. Changes in connective tissue an in bones, pains, articular stiffness, synovial proliferation with tumefaction and in the late stages bone destruction and ankylosing. In autoimmune diseases (Rheumatoid Arthritis) we may met the following steps: The setting of the immune complexes through an antigen excess followed by complement addition, platelet injury leading to the releasing of vasoactive biologic amines (kallikrein, bradyquinin, bradyquininogen, etc.), the increase of the vascular permeability by the factors released by platelets and white cells, the localisation of the immune complexes on vascular walls, releasing of chemo tactic factors (opsonines), tissue infiltration by polynuclear cells and macrophages with immune complexes ingestion, lysosome realising leading to increase in tissue proteolysis (rheumatic factor, reactive c protein, plasma immunoglobuline, a.s.o.).
The histo biochemical level is represented by biochemical changes in the tissues, at the cellular level. The cellular membrane may be damaged by the poly-unsaturated fatty acids (phospholipids) per oxidation leading to eicosanoid formation (arachidonic acid, prostaglandin’s, Thromboxanes, leucotriens and other lipoxins). The chemical species called Oxygen Free Radicals (OFR) which is ubicuitary because they are made up and released by cells (especially leucocyte cells) and which are close related with lipid per oxidation. The most important OFR are: the single turning rapidly into super oxide, a species with high toxicity and able to initiate some chain reactions; the hydrogen peroxide, less noxious but able to form oxidril radical more toxic.
Tissues have natural protection by the Antioxidative System (AOS): superoxid-dismutase (SOD), catalase, peroxidase, cytocronoxidases and macrocortin (lipomodulin) an A2 pfospholipase inhibitor, substances which have the ability to protect against the toxic action of OFR in excess.
In pathological conditions this protection is ineffective. The excess of OFR may lead to cell destruction, proteolysis, with auto antigens production.
The quantic level is that of intra-atomic changes. There are more possible atomic and molecular orbital depending of number of electrons, spin movement and molecular energetical charge. When a molecule receives energy it become “exited” and the electrons begin to change their orbital. In the Plasma (the forth state of matter) all the electrons are leaving the atoms because of the great energy, the Maxine of oxidation. At the beginning of the OFR studies they find them in radiation conditions. This confer them an oxidative power which depend both on chemical species (super oxides, oxidril radicals) and of the quantic excitation.
In the body the quantic excitation may depend on different factors like: toxic substances, ionising radiations (exposure to the sun light), microbian or viral invasion, traumas, some metallic ions, exogenous oxidative enzymes. a.s.o.
Interrelations between the pathogenic levels.
This frame of pathogenic levels is artificial but necessary for our intention of changing the medical thinking upon the usefulness if the nosological entities, (different diseases, different treatments) and to propose an other approach, more ethiopatogenical which may lead to a different understanding of the treatment.
There are important interdependences between pathogenical levels difficult to separate.
First important observation is that is an important difference between the molecular oxygen, which helps us to move the acid conditions in the tissues (respiration, tissue oxygenation) and the OFR species. The molecular oxygen is not “exited”, their electrons are in stable orbital and are no ready to level their substrate, the oxygen molecules. The OFR species are “exited”, they dun proteolysis, cellular destructions. In pathological inflammatory conditions (like in reumativcal diseases)
They grow in number and they become more and more excited. Way? Genetical determination by HLA, possible microbian or viral aggression and immune complex apparition.
The firs autoagression is that of the OFR species which, as we say, grow in number and became exited. The consequence is the proteolysis witch lead to the immune complex formation and a second auto aggression, the immune auto aggression is at the start.
We repeat. In some special conditions we call pathological, and only in some conditions, the OFR, present all over the body in health conditions, grows in number and became more and more excited, more and more, fool of energies (we call quantic energies), more and more loosing electrons. In pathological conditions a lot of OFR may appear in soft tissues as muscles, connective tissue (sinovia, tendons, fasciae) and they burn this tissues. The immediate consequences are: pain, stiffness, redness, swelling (calor, rubor, dolor, tumor, as in all inflammatory conditions). Proteolysis is the chemical effect by which OFR may reduce their excitability and even may scavenge them. This is the “natural” kind of self treatment the body has. More consequences: Denaturised proteins stimulate the Immune complex formation and after several moth, or years, of pains, swelling and treatment with AINS, or other anti-inflammatory medicines, joints may be affected and even ankylosing may occur.
That is the case in arthitis. In AS the Para vertebral destroyed connective tissues and muscles (the OFR aggression is focused on the spine- genetic aleatory determination).
Became fibrous (fibrous Para vertebral ligaments with a fibrous ankylosing) and after another time the ankylosing will turn in osseous ankylosing. Because of the long period of big muscular and connective pains patients are obliged to reach vicious position in flexion and the ankylosing follow it.
In Osteoarthrosis is the same situation but with less important OFR aggression. Proteolysis leads to the articular deformation, condensing osteitis.
We come back to our mind. The first auto aggression is the OFR aggression. The mesenchime, muscle, connective tissue and only after a long period of pains and swelling the joint and generally the bones are involved. The firs injury is in the soft tissue.
That means that the pathogenical differences between different rheumatic diseases, arthritis, AS, Osteoarthritis, is genetically aleatory determined and maybe extern influences.
Immediate consequences: All the Anti-inflammatory treatments and immune treatments skips the quantic level auto aggression and may no change the ill evolution, no mach recovery in rheumatic diseases.
Our PL treatment with a dilution of little chains of polypeptides may be a help in the local scavenge of OFR. The natural scavenge (AOS) with superoxid- dis- mutase, catalase, different kinds of peroxidases has no a real power in pathological conditions, even C Vitamin, E and A Vitamin, Selenium, by food or administrated as a supplement has no power to scavenge OFR. By local and regional injections with PL we offer a very good local scavenger of the OFR species.
The Homoeopahtical dilutions of PL (PL2 or 3- Hahnemannian dilutions) by their clusters (water crystals) may help by their chemical phantoms which may scavenge OFR like the chemical species (Polypeptides).
Second important observation. In the medical literature there is an ambiguity between the healthy Oxygen species witch help us to avoid cellular acidosis and the OFR species which are weapons as antimicrobian or antiviral aggression.
The healthy oxygen species are in a low quantic excitation and for that has no a proteolysis effect. The OFR species have a great energetic charge and that means an excited quantic state with a power fool force of oxidation, of proteolysis.
For that the intravenous treatment, we use to, with oxygen peroxide in low dilution may help against cellular acidosis and is no harm as an OFR.
Vsi revmatične bolezni enake pathogenical pogoje. Razlike med artritis, Kot in Osteoarthosis je naključni HLA odvisni in za izven pogojev.
Bolezen je OFR Autoagression. Imunološka Auto agresija je sekundarna.
Zdravljenje PL je lokalna OFR smetar.
Copyright © Geo Savulescu 2003